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The Effect of SARS-CoV-2 Vaccination on B-Cell Phenotype in Systemic Sclerosis Patients.

Authors :
Pellicano, Chiara
Colalillo, Amalia
Basile, Valerio
Marino, Mariapaola
Basile, Umberto
La Gualana, Francesca
Mezzaroma, Ivano
Visentini, Marcella
Rosato, Edoardo
Source :
Journal of Personalized Medicine; Sep2022, Vol. 12 Issue 9, pN.PAG-N.PAG, 11p
Publication Year :
2022

Abstract

Objective: to assess the influence of SARS-CoV-2 mRNA vaccine on B-cell phenotypes in systemic sclerosis (SSc). Methods: peripheral blood B-cell subpopulations were evaluated before (t1) and 3 months (t3) after the second dose of vaccine in 28 SSc patients. Peripheral blood B-cell subpopulations were evaluated in 21 healthy controls (HCs) only at t1. Anti-spike IgG levels were evaluated at t3 in both cohorts. Results: SSc patients presented higher naive, double-negative, and CD21<superscript>low</superscript> B cells compared to HCs. IgM-memory and switched-memory B cells were lower in SSc patients than HCs. No differences in anti-spike IgG levels after vaccination were observed between SSc patients and HCs. Anti-spike IgG levels after vaccination were lower in SSc patients with increased CD21<superscript>low</superscript> B cells at baseline compared to SSc patients with normal CD21<superscript>low</superscript> B cells. A positive correlation was found between IgG levels and naive B cells. A negative linear correlation was shown between IgG levels and IgM-memory, switched-memory, double-negative, and CD21<superscript>low</superscript> B cells. Conclusions: SARS-CoV-2 mRNA vaccine response is normal in SSc patients not undergoing immunosuppressive therapy. The normal number of naive B cells is a positive marker of antibody response. The increased percentage of CD21<superscript>low</superscript> B cells represents a negative marker of antibody response. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20754426
Volume :
12
Issue :
9
Database :
Complementary Index
Journal :
Journal of Personalized Medicine
Publication Type :
Academic Journal
Accession number :
159334580
Full Text :
https://doi.org/10.3390/jpm12091420