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Association between toxic and essential metals in blood and global DNA methylation among electronic waste workers in Agbogbloshie, Ghana.
- Source :
- Environmental Science & Pollution Research; Oct2022, Vol. 29 Issue 48, p72946-72956, 11p
- Publication Year :
- 2022
-
Abstract
- Aberrant global DNA methylation status is a known biomarker for increased disease risk, especially cancer. There is little published data on the association between toxic and essential metal mixtures and global DNA methylation in electronic waste (e-waste) workers. We aimed to establish the association between toxic and essential metals in blood and the effect of their interactions on global DNA methylation among e-waste recyclers and a reference group in Ghana. We used ICP-MS to measure the level of five metals (Se, Zn, Mn, Cd, and Pb) in the blood of 100 e-waste workers and 51 controls. We quantified blood DNA methylation levels of LINE-1 as an indicator of global DNA methylation. Cd, Mn, and Se levels were significantly higher in the reference group than in e-waste workers. Only Pb was significantly higher in the e-waste workers compared to the controls. Our linear regression analysis results showed a significant inverse association between Zn and LINE-1 DNA methylation (β<subscript>Zn</subscript> = − 0.912; 95% CI, − 1.512, − 0.306; p = 0.003) which corresponds to a 0.009 decrease in %LINE-1 methylation (95% CI, − 0.015, − 0.003; p = 0.003) for a 1% increase in Zn concentration. Potential interactions between Cd and Zn on global DNA methylation were observed. In summary, co-exposure to toxic and essential metals is associated with global (LINE-1) DNA methylation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09441344
- Volume :
- 29
- Issue :
- 48
- Database :
- Complementary Index
- Journal :
- Environmental Science & Pollution Research
- Publication Type :
- Academic Journal
- Accession number :
- 159411727
- Full Text :
- https://doi.org/10.1007/s11356-022-20954-z