Meeting Report: 47th Annual Meeting of the "Arbeitsgemeinschaft Dermatologische Forschung".

Maike Effern Adoptive T-Cell Therapy Targeting Different Gene Products Reveals Diverse and Context Dependent Immune Evasion in Melanoma Adoptive T-cell therapy (ACT) has emerged as a powerful treatment option for patients with metastatic melanoma. In our work, we demonstrated in animal models that in vivo targeting of antigens to cDC2 cells induced efficient CD4+ T-cell responses, while antigen targeting to cDC1 cells resulted in cytotoxic CD8+ T-cell responses. We furthermore showed that the pro- and anti-inflammatory versions of Th17 cells correlated with their antigen specificity, with C. albicans-specific Th17 cells being pro-inflammatory but S. aureus-specific Th17 cells being anti-inflammatory. As key cells of the immune system, dendritic cells not only mediate the initiation of T-cell immune responses, they also direct the differentiation into the needed effector T cells in dependency on the original acquired pathogen. [Extracted from the article]