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Recent Progress on Transition-Metal-Mediated Reductive C(sp3)–O Bond Radical Addition and Coupling Reactions.
- Source :
- Synthesis; Oct2022, Vol. 54 Issue 20, p4426-4446, 21p
- Publication Year :
- 2022
-
Abstract
- In this short review, we summarize the recent developments on thermo-driven C(sp<superscript>3</superscript>)–O bond radical scission methods and their applications in the construction of C(sp<superscript>3</superscript>)–C bonds via conjugate addition with activated double bonds and reductive coupling mediated by economic 3d metals, in particular nickel. We have arranged the review based on three approaches for C(sp<superscript>3</superscript>)–O bond radical scission (vide infra). After generating the radical intermediates, their subsequent transformation into C(sp<superscript>3</superscript>)–C bonds enabled by C(sp<superscript>3</superscript>)–O cross-electrophile coupling with carbon electrophiles is discussed in detail. 1 Introduction 2 Direct Single-Electron Transfer to a C(sp<superscript>3</superscript>)–O Bond 3 Radical Scission of Activated C(sp<superscript>3</superscript>)–O Bonds via Single-Electron Transfer to Protecting Groups 4 In Situ Activation of Alcohols 5 Summary and Outlook [ABSTRACT FROM AUTHOR]
- Subjects :
- ADDITION reactions
DOUBLE bonds
RADICALS (Chemistry)
Subjects
Details
- Language :
- English
- ISSN :
- 00397881
- Volume :
- 54
- Issue :
- 20
- Database :
- Complementary Index
- Journal :
- Synthesis
- Publication Type :
- Academic Journal
- Accession number :
- 159491382
- Full Text :
- https://doi.org/10.1055/a-1848-3005