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Synthesis and crystal structure of topiramate azidosulfate at 90 K and 298 K.

Authors :
Priyanka, Prabhakar
Jayanna, Bidarur K.
Kumar, Haruvegowda Kiran
Vinaya
Divakara, Thayamma R.
Yathirajan, Hemmige S.
Glidewell, Christopher
Parkin, Sean
Source :
Acta Crystallographica Section E: Crystallographic Communications; Oct2022, Vol. 78 Issue 10, p984-Sup-10, 15p
Publication Year :
2022

Abstract

The low (90 K) and room (298 K) temperature crystal structures of topiramate azidosulfate [systematic name 2,3:4,5-bis-O-(1-methylethylidene)-ß-D-fructopyranose azidosulfate], C12H19N<subscript>3</subscript>O8S, an intermediate in the synthesis of the anti-convulsant drug topiramate, are described. Topiramate azidosulfate (I) finds use as a reference impurity standard for topiramate. A modified synthesis and some spectroscopic details are also presented. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20569890
Volume :
78
Issue :
10
Database :
Complementary Index
Journal :
Acta Crystallographica Section E: Crystallographic Communications
Publication Type :
Academic Journal
Accession number :
159543941
Full Text :
https://doi.org/10.1107/S2056989022008799