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Efficacy and safety of daily home-based transcranial direct current stimulation as adjunct treatment for bipolar depressive episodes: Double-blind sham-controlled randomized clinical trial.

Authors :
Jangwon Lee
Chan Woo Lee
Yoonjeong Jang
Ji Seon You
Yun Seong Park
Eunjeong Ji
Hyeona Yu
Sunghee Oh
Hyun A. Ryoo
Nayoung Cho
Ji Yoon Park
Joohyun Yoon
Ji Hyun Baek
Hye Youn Park
Tae Hyon Ha
Woojae Myung
Source :
Frontiers in Psychiatry; 9/20/2022, Vol. 13, p1-10, 10p
Publication Year :
2022

Abstract

Background Although transcranial direct current stimulation (tDCS) is known to be a promising therapeutic modality for unipolar depression, the efficacy and safety of tDCS for bipolar depressive episodes (BD) are still unknown and clinical trials of home-based tDCS treatment are scarce. As a result, we set out to investigate the efficacy and safety of home-based tDCS for the treatment BD. Methods Participants (n = 64), diagnosed as bipolar disorder as per the diagnostic and statistical manual of mental disorders (DSM-5), were randomly assigned to receive tDCS. Hamilton Depression Rating Scale (HDRS-17) scores were measured at the baseline, week 2, 4, and 6, and home-based tDCS (for 30 min with 2 mA) was self-administered daily. Results Of the 64 patients (15.6% bipolar disorder I, 84.4% bipolar disorder II), 41 patients completed the entire assessment. In the intention-to-treat analysis, time-group interaction for the HDRS-17 [F <subscript>(3, 146.36)</subscript> = 2.060; p = 0.108] and adverse effect differences between two groups were not statistically significant, except the pain score, which was higher in the active group than the sham group (week 0--2: p < 0.01, week 2--4: p < 0.05, and week 4--6: p < 0.01). Conclusion Even though we found no evidence for the efficacy of home-based tDCS for patients with BD, this tool was found to be a safe and tolerable treatment modality for BD. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
16640640
Volume :
13
Database :
Complementary Index
Journal :
Frontiers in Psychiatry
Publication Type :
Academic Journal
Accession number :
159547566
Full Text :
https://doi.org/10.3389/fpsyt.2022.969199