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Epigenetic profiling reveals a subset of pediatric-type glioneuronal tumors characterized by oncogenic gene fusions involving several targetable kinases.
- Source :
- Acta Neuropathologica; Nov2022, Vol. 144 Issue 5, p1049-1052, 4p
- Publication Year :
- 2022
-
Abstract
- These data suggest a remarkably wide range of different gene fusions that drive tumors within this epigenetic group and in parallel highlights attractive therapeutic targets in particular for patients with incomplete surgical resection or tumor progressions. Given their morphological overlap with other GNTs and the lack of a pathognomonic alteration, we provisionally suggest the term "glioneuronal tumor kinase-fused" (GNT KinF A) to describe this novel group of tumors. To identify novel epigenetic subgroups of GNTs, we used an unsupervised visualization approach with a comprehensive dataset of DNA methylation profiles covering the entire spectrum of existing molecular CNS tumor classes [[2]]. [Extracted from the article]
- Subjects :
- GENE fusion
GENE expression profiling
KINASES
Subjects
Details
- Language :
- English
- ISSN :
- 00016322
- Volume :
- 144
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Acta Neuropathologica
- Publication Type :
- Academic Journal
- Accession number :
- 159549242
- Full Text :
- https://doi.org/10.1007/s00401-022-02492-7