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Identification of Two Novel Immune Subtypes Characterized by Distinct Prognosis and Tumor Microenvironment in Osteosarcoma.

Authors :
Yao, Shunhan
Deng, Meiling
Du, Xiaojing
Chen, Qingfeng
Huang, Rongzhi
Source :
Journal of Immunology Research; 10/8/2022, p1-12, 12p, 2 Diagrams, 2 Charts, 6 Graphs
Publication Year :
2022

Abstract

Osteosarcoma is a kind of primary malignant tumor of bone. In recent years, its therapeutic effect and prognostic survival are dissatisfactory. The tumor immune microenvironment (TIME) reflects immune status of patients, but it is little known in osteosarcoma. Therefore, this study attempts to conduct a comprehensive analysis to explore TIME of osteosarcoma and identify TIME-related subtypes for clinical management and treatment. We successfully established two novel tumor immune infiltration clusters (TIIC) which are characterized by difference of microenvironment and immune-related biological processes. High tumor immune infiltration cluster (H-TIIC) subtypes with higher immune infiltration score shows a better overall survival. Further, the two immune subtypes are shown to differ in immunotherapy and chemotherapy. The results would be helpful for clinical decision in osteosarcoma. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
23148861
Database :
Complementary Index
Journal :
Journal of Immunology Research
Publication Type :
Academic Journal
Accession number :
159554516
Full Text :
https://doi.org/10.1155/2022/2181525