Back to Search
Start Over
Acute idiosyncratic liver injury after Cladribine treatment for multiple sclerosis: first case report and review on associated hepatic disorders.
- Source :
- Multiple Sclerosis Journal; Nov2022, Vol. 28 Issue 13, p2142-2145, 4p
- Publication Year :
- 2022
-
Abstract
- In recent years, several disease-modifying therapies have been developed for the treatment of multiple sclerosis (MS). Cladribine transiently depletes B and T lymphocytes, with subsequent gradual cell recovery. No cases are reported in literature describing Cladribine drug-induced liver injury (DILI). We describe the case of a 19-year-old woman who developed acute idiosyncratic liver injury 12 days after treatment with Cladribine. Post-marketing adverse event reporting is of paramount importance to allow an early recognition and treatment. Moreover, evaluation of the physiopathological mechanism underlying drug-induced hepatic toxicity can provide clinicians with valuable instruments for prevention and treatment. [ABSTRACT FROM AUTHOR]
- Subjects :
- LIVER injuries
MULTIPLE sclerosis
T cells
HEPATOTOXICOLOGY
B cells
Subjects
Details
- Language :
- English
- ISSN :
- 13524585
- Volume :
- 28
- Issue :
- 13
- Database :
- Complementary Index
- Journal :
- Multiple Sclerosis Journal
- Publication Type :
- Academic Journal
- Accession number :
- 159693852
- Full Text :
- https://doi.org/10.1177/13524585221125360