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Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (Safr'Inside TM) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders.

Authors :
Wauquier, Fabien
Boutin-Wittrant, Line
Pourtau, Line
Gaudout, David
Moras, Benjamin
Vignault, Adeline
Monchaux De Oliveira, Camille
Gabaston, Julien
Vaysse, Carole
Bertrand, Karène
Abrous, Hélène
Capuron, Lucile
Castanon, Nathalie
Vauzour, David
Roux, Véronique
Macian, Nicolas
Pickering, Gisèle
Wittrant, Yohann
Source :
Nutrients; Apr2022, Vol. 14 Issue 7, p1511-1511, 15p
Publication Year :
2022

Abstract

Increases in oxidative stress have been reported to play a central role in the vulnerability to depression, and antidepressant drugs may reduce increased oxidative stress in patients. Among the plants exerting anti-inflammatory and anti-oxidant properties, saffron, a spice derived from the flower of Crocus sativus, is also known for its positive effects on depression, potentially through its SSRI-like properties. However, the molecular mechanisms underlying these effects and their health benefits for humans are currently unclear. Using an original ex vivo clinical approach, we demonstrated for the first time that the circulating human metabolites produced following saffron intake (Safr'Inside<superscript>TM</superscript>) protect human neurons from oxidative-stress-induced neurotoxicity by preserving cell viability and increasing BNDF production. In particular, the metabolites significantly stimulated both dopamine and serotonin release. In addition, the saffron's metabolites were also able to protect serotonergic tone by inhibiting the expression of the serotonin transporter SERT and down-regulating serotonin metabolism. Altogether, these data provide new biochemical insights into the mechanisms underlying the beneficial impact of saffron on neuronal viability and activity in humans, in the context of oxidative stress related to depression. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20726643
Volume :
14
Issue :
7
Database :
Complementary Index
Journal :
Nutrients
Publication Type :
Academic Journal
Accession number :
159714238
Full Text :
https://doi.org/10.3390/nu14071511