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Desmopressin Acetate Before Percutaneous Ultrasound-Guided Kidney Biopsy in Patients with Renal Failure -- Is it Really Beneficial?
- Source :
- Indian Journal of Nephrology; Sep/Oct2022, Vol. 32 Issue 5, p430-434, 5p
- Publication Year :
- 2022
-
Abstract
- Introduction: The most common complication of percutaneous renal biopsy is bleeding, which can be seen in up to one-third of cases. The aim of this study was to evaluate the effect of prebiopsy administration of intranasal desmopressin acetate in reducing the incidence of biopsy-related bleeding complications in patients with significant renal dysfunction who underwent renal biopsy. Methods: This was a retrospective, observational study of percutaneous native renal biopsies performed at our center from July 2014 to June 2018. Bleeding complication rates of patients with renal failure (estimated glomerular filtration rate [eGFR] <30 mL/minute/1.73 m2 ) who received desmopressin and those who did not receive desmopressin were compared. Results: Desmopressin administration before renal biopsy in patients with eGFR <30 mL/minute/1.73 m2 was associated with a significant reduction of bleeding complications (major and minor together; P = 0.025) and no significant reduction in major complications (P = 0.616) or intervention rates (P = 0.251) when compared with a group that did not receive desmopressin. Conclusions: While prebiopsy intranasal desmopressin use was associated with a significant reduction of overall bleeding complications including major and minor complications, there was no reduction in the rate of other major complications and interventions. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09714065
- Volume :
- 32
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Indian Journal of Nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 159751852
- Full Text :
- https://doi.org/10.4103/ijn.IJN_553_20