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ortho‐Acylation of Aryl Iodides Enabled with Imides via Palladium/Norbornene/CuI Catalysis.
- Source :
- Advanced Synthesis & Catalysis; 10/18/2022, Vol. 364 Issue 20, p3506-3511, 6p
- Publication Year :
- 2022
-
Abstract
- Herein, a three component Catellani‐type reaction catalyzed by the Palladium/Norbornene/CuI (Pd/NBE/CuI) cooperative system by using N‐acylph‐thalimides as acyl electrophiles is reported, which gives access to a series of aromatic ketones. The transformation is performable in the presence of water, albeit with decreased reaction yield. The additive CuI was crucial to facilitate the cleavage of C(O)−N bond of imide. This protocol showed broad substrate scope: both alkyl and aryl acyl groups could be installed at the ortho‐position of aryl iodides; alkenes and boronic acids can be used as termination reagents. [ABSTRACT FROM AUTHOR]
- Subjects :
- ARYL iodides
PALLADIUM
ACYL group
IMIDES
CHEMICAL yield
SUZUKI reaction
Subjects
Details
- Language :
- English
- ISSN :
- 16154150
- Volume :
- 364
- Issue :
- 20
- Database :
- Complementary Index
- Journal :
- Advanced Synthesis & Catalysis
- Publication Type :
- Academic Journal
- Accession number :
- 159764685
- Full Text :
- https://doi.org/10.1002/adsc.202200801