Design, synthesis and evaluation in vitro antibacterial activity of new 1,2,3-triazole derivatives.

In the current work, 1,2,3-triazole and 1,3,4-thiadiazole rings were combined in the same structure via a multi-steps synthetic pathway to present a series of 1,2,3-triazole derivatives. The newly synthesized compounds were characterized by FT-IR, 1H-NMR, 13C-NMR and mass spectra. The final compounds and their precursors were in vitro tested as antibacterial agents by well diffusion method against the Gram-negative strains (Helicobacter Pylori, Klebsiella pneumonia, Escherichia coli O157) and the Gram-positive strain of Staphylococcus aureus. The bioassay indicated that all the tested compounds were not active or possessed a week to excellent antibacterial activity depending on the type of the tested bacteria and the structure of the target compounds. [ABSTRACT FROM AUTHOR]