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TIGIT Monoallelic Nonsense Variant in Patient with Severe COVID-19 Infection, Thailand.
- Source :
- Emerging Infectious Diseases; Nov2022, Vol. 28 Issue 11, p2350-2352, 3p, 1 Graph
- Publication Year :
- 2022
-
Abstract
- A heterozygous nonsense variant in the TIGIT gene was identified in a patient in Thailand who had severe COVID-19, resulting in lower TIGIT expression in T cells. The patient's T cells produced higher levels of cytokines upon stimulation. This mutation causes less-controlled immune responses, which might contribute to COVID-19 severity. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10806040
- Volume :
- 28
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Emerging Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 159889079
- Full Text :
- https://doi.org/10.3201/eid2811.220914