Nanotechnology-based approaches in diagnosis and treatment of epilepsy.

Over 70 million people worldwide are suffering from different forms of epilepsy. Despite significant advances in the past few decades, between 20 and 40% of these patients would develop medically intractable epilepsy. Technological advances are essential in the identification of novel reliable diagnostic and therapeutic approaches and in improving the quality of health services for patients with epilepsy. Nanotechnology-based approaches offer potential effective methods to improve seizure detection and treatment. Nanomedicine-based nanoparticles can promote anti-convulsant therapy through improving pharmacokinetics and biodistribution of drugs as well as providing more efficient drugs and active molecule delivery systems. Furthermore, nanotechnology-based approaches can tackle barriers to a better diagnosis of epilepsy via the improvement of bioelectrical recording approaches as well as the development of novel biomarkers and imaging systems. In the present review, we summarized the current nanotechnology-based advances in the diagnosis and treatment of epilepsy and discussed how the knowledge of these achievements could convey a better treatment outcome in epilepsy. [ABSTRACT FROM AUTHOR]