Back to Search
Start Over
Survival outcomes of hypomethylating agents maintenance therapy in new diagnosed AML patients: Real experience data.
- Source :
- Northern Clinics of Istanbul; 2022, Vol. 9 Issue 4, p331-336, 6p
- Publication Year :
- 2022
-
Abstract
- OBJECTIVE: Acute myeloid leukemia (AML) is a hematological malignancy that frequently affects elderly population. With introducing the hypomethylating agents (HMAs) in elderly AML treatment, survival rates and quality of life have improved. However, long-term management in elderly and frail patients is still a challenge. In the present study, we aimed to determine whether HMA maintenance therapy is required until disease progression in frail and elderly AML patients by examining with a real-life data. METHODS: In a multicenter study, we analyzed non-promyelocytic elderly AML patients who were treated with first-line azacitidine or decitabine monotherapy in two different groups, retrospectively. While patients were treated with HMA until progression in the maintenance group, 6+3 cycles of azacitidine or decitabine were administered as a standard care of elderly AML patients in the non-maintenance group. Survival outcomes were compared between the groups. RESULTS: HMA therapy was maintained until progression in 20 patients, and HMA therapy was terminated after 6+3 cycles in 21 patients. Patients received a median of 6 (1–14) HMA cycles during follow-up time. The median 7.5 months of overall survival were observed (2–17 months) in maintenance and 3 months (1–13 months) in non-maintenance groups (p=0.001). CONCLUSION: Despite long-term exposure to HMA may appear as a risk factor for complications and toxicities in elderly and frail AML patients, the maintenance of therapy until disease progression provides a significant survival advantage. Therefore, we suggest that HMA therapy should continue until disease progression regardless the sort of HMA. [ABSTRACT FROM AUTHOR]
- Subjects :
- ACUTE myeloid leukemia
SURVIVAL rate
QUALITY of life
AZACITIDINE
OVERALL survival
Subjects
Details
- Language :
- English
- ISSN :
- 21484902
- Volume :
- 9
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Northern Clinics of Istanbul
- Publication Type :
- Academic Journal
- Accession number :
- 159965555
- Full Text :
- https://doi.org/10.14744/nci.2021.42800