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ROS‐scavenging and antimicrobial polysaccharide hydrogel for methicillin‐resistant staphylococcus aureus‐infected diabetic wound healing.
- Source :
- Nano Select; Nov2022, Vol. 3 Issue 11, p1537-1547, 11p
- Publication Year :
- 2022
-
Abstract
- Bacterial infection can cause delay in wound healing, and reactive oxygen species (ROS) was accumulated in wounds, which threaten patients' lives. Therefore, it needs to develop a multifunctional hydrogel for infected wound healing. Here, a multifunctional QAS‐CS@GA‐GM hydrogel with antibacterial and antioxidant property, established by the self‐adaptive covalent bond, is prepared aiming to eradicate bacteria and eliminate ROS. It is observed that QAS‐CS@GA‐GM hydrogel displays remarkable ability of clearing ROS and killing bacteria in vitro. With its antibacterial and antioxidant activity, QAS‐CS@GA‐GM hydrogel significantly accelerates the MRSA‐infected wound closure and reduces inflammatory, when QAS‐CS@GA‐GM hydrogel was applied to wound sites. Collectively, the research suggests that a self‐adaptive QAS‐CS@GA‐GM hydrogel is a promising wound dressing as antibacterial and ROS‐scavenging dressing for bacterial‐infected wound. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- Volume :
- 3
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Nano Select
- Publication Type :
- Academic Journal
- Accession number :
- 160065446
- Full Text :
- https://doi.org/10.1002/nano.202200117