Response Surface Optimization of Amination Resin for the Adsorption of Ceftriaxone Sodium.

Ceftriaxone sodium (CS) is a commonly used antibiotic drug that is frequently detected in surface water and sewage plant drainage. To enhance the adsorption performance of the adsorbent resin for CS, the amino-modified oxygenated ultra-high cross-linked adsorbent resin GNH-01 was prepared by Friedel-Crafts reaction and chemical modification using a low cross-linked polystyrene-divinylbenzene resin (CMCPS) as the backbone. Characterization analysis showed that the resin surface has loose small pores, large specific surface area, and abundant for-vacancy structure, and the surface is rich in oxygen- and nitrogen-containing functional groups. The effects of time, temperature, initial concentration, solution pH and resin dosage on the adsorption effect were investigated with CS as the target pollutant, and the adsorption mechanism was proposed in combination with the adsorption kinetics. The results showed that the best adsorption effect was achieved at an initial concentration of 40 mg/L, a dosage of 1 g/L, a temperature of 30 ° and pH 6.18(Q_e=38.62 mg/g, removal rate 96.55%). The kinetic study showed that the adsorption process was in good agreement with the proposed secondary kinetic equation (R²>0.98). CS was both physisorbed and chemisorbed on the resin. The introduction of functional groups enhanced the adsorption performance of the resin due to the charge interaction between the adsorbent and CS. In addition, the hydrogen bonding interaction also increased the adsorption amount of the adsorption process. The Box-Behnken model of response surface method was used to optimize the experimental conditions, and the effects of the factors and their interactions on the adsorption effect were explored to determine the optimal adsorption conditions. Using 5.00% NaOH solution as its desorption solution, the GNH-01 resin was regenerated with good effect and could be reused. This study provides a mechanistic basis and data support for the application in CS wastewater resource treatment. [ABSTRACT FROM AUTHOR]