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Ligand Growing Experiments Suggested 4-amino and 4-ureido pyridazin-3(2 H)-one as Novel Scaffold for FABP4 Inhibition.
- Source :
- Pharmaceuticals (14248247); Nov2022, Vol. 15 Issue 11, p1335, 30p
- Publication Year :
- 2022
-
Abstract
- Fatty acid binding protein (FABP4) inhibitors are of synthetic and therapeutic interest and ongoing clinical studies indicate that they may be a promise for the treatment of cancer, as well as other diseases. As part of a broader research effort to develop more effective FABP4 inhibitors, we sought to identify new structures through a two-step computing assisted molecular design based on the established scaffold of a co-crystallized ligand. Novel and potent FABP4 inhibitors have been developed using this approach and herein we report the synthesis, biological evaluation and molecular docking of the 4-amino and 4-ureido pyridazinone-based series. [ABSTRACT FROM AUTHOR]
- Subjects :
- CARRIER proteins
FATTY acids
MOLECULAR docking
CANCER treatment
PYRIDAZINONES
Subjects
Details
- Language :
- English
- ISSN :
- 14248247
- Volume :
- 15
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Pharmaceuticals (14248247)
- Publication Type :
- Academic Journal
- Accession number :
- 160205596
- Full Text :
- https://doi.org/10.3390/ph15111335