Back to Search
Start Over
Sex differences in the regulation of experimentally induced autoantibodies in (NZB x NZW)F1 mice.
- Source :
- Immunology; Dec80, Vol. 41 Issue 4, p819-823, 5p
- Publication Year :
- 1980
-
Abstract
- The ability to induce autoantibodies to erythrocytes in male and female (NZB × NZW)F<subscript>1</subscript> mice was examined. Female (NZB × NZW)F<subscript>1</subscript> mice were shown to produce significantly more autoantibody than the male (NZB × NZW)F<subscript>1</subscript> mice. The regulation of this experimentally induced autoantibody was studied by examining the ability of male and female (NZB × NZW)F<subscript>1</subscript> mice to generate antigen- specific suppressor cells. A sex difference was found in the ability to generate these suppressor cells. Male mice generated antigen-specific suppressor cells in response to rat RBC which were capable of suppressing the experimental induction of red cell autoantibodies whereas female mice were unable to generate these antigen-specific suppressor cells. [ABSTRACT FROM AUTHOR]
- Subjects :
- AUTOANTIBODIES
ANTIGENS
SUPPRESSOR cells
T cells
AUTOIMMUNITY
IMMUNOGLOBULINS
Subjects
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 41
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 16022889