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Alpinumisoflavone Exhibits the Therapeutic Effect on Prostate Cancer Cells by Repressing AR and Co-Targeting FASN- and HMGCR-Mediated Lipid and Cholesterol Biosynthesis.
- Source :
- Life (2075-1729); Nov2022, Vol. 12 Issue 11, p1769, 13p
- Publication Year :
- 2022
-
Abstract
- Moreover, AIF treatment led to cell death via activation of the caspase-associated apoptotic pathway in PCa cells. Cell Growth Analysis To investigate the therapeutic effects of AIF on cell growth, PCa cells were seeded in the 96-well plates (1 × 10 SP 4 sp cells/well) and incubated overnight. As expected, targeting the emerging cancer hallmarks and PCa-specific vulnerability genes, such as FASN and HMGCR [[44]], AIF treatment caused the attenuation of PCa cell growth, migration, and invasion. [Extracted from the article]
Details
- Language :
- English
- ISSN :
- 20751729
- Volume :
- 12
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Life (2075-1729)
- Publication Type :
- Academic Journal
- Accession number :
- 160232096
- Full Text :
- https://doi.org/10.3390/life12111769