Understanding Retinal Vasculitis Associated with Brolucizumab: Complex Pathophysiology or Occam's Razor?

Keywords: Brolucizumab; retinal vasculitis; occlusive vasculitis; intraocular inflammation EN Brolucizumab retinal vasculitis occlusive vasculitis intraocular inflammation 1508 1510 3 11/18/22 20220801 NES 220801 Recent reports of retinal vasculitis (some cases were also occlusive) after brolucizumab injection has ignited a poorly understood immunogenicity alert in the form of intraocular inflammation and retinal vasculitis. Patients with retinal vasculitis rarely suffer from systemic vasculitis. First being that IOI preceded vasculitis by a few weeks, second, predominantly arterial involvement, third, all the patients had previous anti-VEGFs injections in the past (no treatment naïve patients), fourth all the affected patients were female, and lastly, vasculitis was found to be noninfectious and not related to post-procedure endophthalmitis. [Extracted from the article]