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A Simplified CMV-specific T Cell Transfer Targeting Drug-resistant CMV Retinitis.

Authors :
Mo, Wenjian
Liang, Yuqin
Wang, Caixia
Zhang, Yuehong
Source :
Ocular Immunology & Inflammation; Aug2022, Vol. 30 Issue 6, p1541-1543, 3p
Publication Year :
2022

Abstract

Among severely immunosuppressed patients resistant or refractory cytomegalovirus (CMV) retinitis is not uncommon, and is potentially blinding in the affected eye. Immunotherapy using CMV-specific cytotoxic T lymphocytes (CTLs) is an emerging and promising alternative for the control of resistant or refractory CMV retinitis. However, highly purified CMV-CTLs are still not available in the majority of medical institutions in China because the generation of CMV-CTLs is labor intensive, time-consuming and expensive. This letter describes the clinical responses to a simplified CMV-CTL immunotherapy aimed at controlling drug-resistant CMV retinitis in two immunodeficient patients. Our cases suggest that the simplified CMV-CTL immunotherapy offers a highly efficient and low-cost solution to drug-resistant CMV retinitis. This immunotherapy strategy targeting drug-resistant CMV retinitis is likely to be cost-effective in the context of a specific patient population. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09273948
Volume :
30
Issue :
6
Database :
Complementary Index
Journal :
Ocular Immunology & Inflammation
Publication Type :
Academic Journal
Accession number :
160260063
Full Text :
https://doi.org/10.1080/09273948.2021.1900876