Analysis of APOE and SLCO1B1 Gene Polymorphism and Correlation with Dyslipidemia in China.

Background: The aim of the study was to analyze the polymorphism of APOE and SLCO1B1 genotype and correlation with blood lipid levels in patients with dyslipidemia in Hunan Province, China. Methods: Concentration of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were retrospectively analyzed from 396 patients with dyslipidemia from 2016 to 2020. The APOE and SLCO1B1 genotypes were detected by PCR-fluorescent probe. SPSS21.0 software was used to analyze the gene frequency and their correlation. Results: The frequency of E3/E3 genotype was the highest in the APOE gene, reaching 64.14%. The concentrations of LDL-C and TC in E4 phenotype group were the highest and were statistically different from those in E2 and E3 phenotype groups (p < 0.05). There were significant differences in E4 phenotype between the dyslipidemia group and the normolipidemia group (p < 0.05). The frequency of *1b/*1b genotype was the highest in the SLCO1B1 gene, reaching 41.41%. The concentrations of TC and LDL-C in the intermediate OA1P1B1 function group were higher than those in the normal OA1P1B1 function group and the differences were statistically significant (p < 0.05). Conclusions: The genotypes of APOE and SLCO1B1 gene are correlated with concentration of TC and LDL-C, and their genotypes frequency distribution have regional differences. [ABSTRACT FROM AUTHOR]