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Pituitary Infiltration by Lymphoma.
- Source :
- Journal of the Endocrine Society; Dec2022, Vol. 6 Issue 12, p1-7, 7p
- Publication Year :
- 2022
-
Abstract
- Lymphoma infiltration to the pituitary is rare. It represents less than 0.5% of all reported pituitary metastases (PMs). Here we present a case series of 3 patients with PMs from a systemic lymphoma. Also, we performed a literature review of the cases reported. We identified additional 31 cases in which non-Hodgkin lymphoma (NHL) was the most common (n = 28, 90%), with large B-cell NHL the most frequent histological subtype (n = 14, 45%). Central hypothyroidism (n = 21, 67%) was the most frequent pituitary deficiency followed by adrenal insufficiency (n = 19, 61%) and diabetes insipidus (DI; n = 18, 58%). Full endocrine recovery was found in only 12% (n = 4) of patients after treatment, and magnetic resonance imaging showed tumor regression in 22% of them. In our series, 2 patients were diagnosed with diffuse large B-cell lymphoma, and 1 had mixed cellularity of classic Hodgkin lymphoma. The mean age was 54 ± 6.92 years. Hypopituitarism and DI were present in all of them, with 100% of mortality because of advanced systemic disease. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 24721972
- Volume :
- 6
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Journal of the Endocrine Society
- Publication Type :
- Academic Journal
- Accession number :
- 160377164
- Full Text :
- https://doi.org/10.1210/jendso/bvac161