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Role of microbes in colorectal cancer therapy: Cross-talk between the microbiome and tumor microenvironment.

Authors :
Cong Xia
Yantao Cai
Shuangyi Ren
Chenglai Xia
Source :
Frontiers in Pharmacology; 11/9/2022, Vol. 13, p1-9, 9p
Publication Year :
2022

Abstract

The human gut microbiota is associated with the development and progression of colorectal cancer, and manipulation of the gut microbiota is a novel strategy for the prevention and treatment of colorectal cancer. Some bacteria have antitumor activity against colorectal cancer, where specific bacteria can improve the tumor microenvironment, activate immune cells including dendritic cells, helper T cells, natural killer cells, and cytotoxic T cells, and upregulate the secretion of pro-tumor immune cytokines such as interleukin-2 and interferon. In this paper, we summarize some bacteria with potential benefits in colorectal cancer and describe their roles in the tumor microenvironment, demonstrate the application of gut microbes in combination with immunosuppressive agents, and provide suggestions for further experimental studies and clinical practice applications. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
16639812
Volume :
13
Database :
Complementary Index
Journal :
Frontiers in Pharmacology
Publication Type :
Academic Journal
Accession number :
160420134
Full Text :
https://doi.org/10.3389/fphar.2022.1051330