Back to Search
Start Over
Human Vδ2 T Cells and Their Versatility for Immunotherapeutic Approaches.
- Source :
- Cells (2073-4409); Nov2022, Vol. 11 Issue 22, p3572, 20p
- Publication Year :
- 2022
-
Abstract
- Gamma/delta (γδ) T cells are innate-like immune effectors that are a critical component linking innate and adaptive immune responses. They are recognized for their contribution to tumor surveillance and fight against infectious diseases. γδ T cells are excellent candidates for cellular immunotherapy due to their unique properties to recognize and destroy tumors or infected cells. They do not depend on the recognition of a single antigen but rather a broad-spectrum of diverse ligands through expression of various cytotoxic receptors. In this manuscript, we review major characteristics of the most abundant circulating γδ subpopulation, Vδ2 T cells, their immunotherapeutic potential, recent advances in expansion protocols, their preclinical and clinical applications for several infectious diseases and malignancies, and how additional modulation could enhance their therapeutic potential. [ABSTRACT FROM AUTHOR]
- Subjects :
- COMMUNICABLE diseases
IMMUNE recognition
CLINICAL medicine
IMMUNE response
Subjects
Details
- Language :
- English
- ISSN :
- 20734409
- Volume :
- 11
- Issue :
- 22
- Database :
- Complementary Index
- Journal :
- Cells (2073-4409)
- Publication Type :
- Academic Journal
- Accession number :
- 160431504
- Full Text :
- https://doi.org/10.3390/cells11223572