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MR1- and HLA-E-Dependent Antigen Presentation of Mycobacterium tuberculosis.
- Source :
- International Journal of Molecular Sciences; Nov2022, Vol. 23 Issue 22, p14412, 11p
- Publication Year :
- 2022
-
Abstract
- MR1 and HLA-E are highly conserved nonclassical antigen-presenting molecules. They can present antigens derived from Mycobacterium tuberculosis to a distinct subset of MR1-restricted or HLA-restricted CD8+ T cells. MR1 presents small microbial metabolites, and HLA-E presents peptides and glycopeptides. In this review, we will discuss the current understanding of MR1 and HLA-E antigen presentation in the context of Mycobacterium tuberculosis infection. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16616596
- Volume :
- 23
- Issue :
- 22
- Database :
- Complementary Index
- Journal :
- International Journal of Molecular Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 160433035
- Full Text :
- https://doi.org/10.3390/ijms232214412