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Beneficial Effects of Traditional Chinese Medicine in the Treatment of Premature Ovarian Failure.
- Source :
- Evidence-based Complementary & Alternative Medicine (eCAM); 11/26/2022, p1-12, 12p, 2 Diagrams, 3 Charts
- Publication Year :
- 2022
-
Abstract
- Premature ovarian failure (POF) is characterized by hormonal disorders, amenorrhea, and premature loss of fertility potential in women of reproductive age. Several studies have been conducted on the effectiveness of traditional Chinese medicine (TCM) in treating POF. TCM relied primarily on apoptosis, immunity, and aging to treat POF based on the studies of domestic and foreign literature. Zuogui pills inhibited mitochondrial-dependent apoptosis in the treatment of POF. Huyang Yangkun formula regulated the downstream of the Bcl-2 family to resist apoptosis through the aquaporin-1 protein. Modified Bazhen decoction regulated apoptosis in POF by regulating X-linked inhibitors of apoptosis protein. Bushen Tianjing recipe was effective in treating POF by promoting angiogenesis and preventing apoptosis. As for immunity, Bushen Jianpi prescription and Er-Xian decoction cured autoimmunity POF models and increased follicular development-related protein expression. Bushen Huoxue Tang improved ovarian function and reduced ovarian inflammation by regulating the Nrf2/Keap1 signaling pathway and T lymphocytes. Taohong Siwu decoction promoted the proliferation and differentiation of granulosa cells of POF mice by regulating the TGF-β1/Smads signaling pathway. In addition, ginsenoside Rg1 and Jiajian Guisheng formula treated POF by regulating cell aging-related mechanisms. Si Wu Tang treated POF by activating the angiogenesis-related proteins. The goal of this review is to serve as a reference for in-depth research into the treatment of POF with TCM and provide inspiration for new diagnostic methods and treatment options. [ABSTRACT FROM AUTHOR]
- Subjects :
- OVARIAN physiology
OVARIES
CELL differentiation
TRANSFORMING growth factors-beta
HERBAL medicine
FOLLICLE-stimulating hormone
NEOVASCULARIZATION
INFLAMMATION
NUCLEAR factor E2 related factor
APOPTOSIS
SIGNAL peptides
MITOCHONDRIA
CELLULAR signal transduction
GRANULOSA cells
CELLULAR aging
OVARIAN diseases
IMMUNITY
AGING
CELL proliferation
MEMBRANE proteins
T cells
CHINESE medicine
CARRIER proteins
THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 1741427X
- Database :
- Complementary Index
- Journal :
- Evidence-based Complementary & Alternative Medicine (eCAM)
- Publication Type :
- Academic Journal
- Accession number :
- 160435321
- Full Text :
- https://doi.org/10.1155/2022/5413504