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Acinetobacter baumannii among Patients Receiving Glucocorticoid Aerosol Therapy during Invasive Mechanical Ventilation, China.

Authors :
Wenchao Zhang
Mei Yin
Wei Li
Nana Xu
Haining Lu
Weidong Qin
Hui Han
Chen Li
Dawei Wu
Hao Wang
Zhang, Wenchao
Yin, Mei
Li, Wei
Xu, Nana
Lu, Haining
Qin, Weidong
Han, Hui
Li, Chen
Wu, Dawei
Wang, Hao
Source :
Emerging Infectious Diseases; Dec2022, Vol. 28 Issue 12, p2398-2408, 11p, 1 Diagram, 4 Charts, 1 Graph
Publication Year :
2022

Abstract

Acinetobacter baumannii is a nosocomial pathogen associated with severe illness and death. Glucocorticoid aerosol is a common inhalation therapy in patients receiving invasive mechanical ventilation. We conducted a prospective cohort study to analyze the association between glucocorticoid aerosol therapy and A. baumannii isolation from ventilator patients in China. Of 497 enrolled patients, 262 (52.7%) received glucocorticoid aerosol, and A. baumannii was isolated from 159 (32.0%). Glucocorticoid aerosol therapy was an independent risk factor for A. baumannii isolation (hazard ratio 1.5, 95% CI 1.02-2.28; p = 0.038). Patients receiving glucocorticoid aerosol had a higher cumulative hazard for A. baumannii isolation and analysis showed that glucocorticoid aerosol therapy increased A. baumannii isolation in most subpopulations. Glucocorticoid aerosol was not a direct risk factor for 30-day mortality, but A. baumannii isolation was independently associated with 30-day mortality in ventilator patients. Physicians should consider potential A. baumannii infection when prescribing glucocorticoid aerosol therapy. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10806040
Volume :
28
Issue :
12
Database :
Complementary Index
Journal :
Emerging Infectious Diseases
Publication Type :
Academic Journal
Accession number :
160445238
Full Text :
https://doi.org/10.3201/eid2812.220347