Electrophysiological correlates of the effect of set size on object switching in working memory.

Previous studies have revealed the effect of set size (the number of activated items) on object switching in working memory, but the underlying neural mechanism remains unclear. In this study, participants were asked to first remember two (small size) or three (large size) two‐digit numbers and the corresponding geometrical figures as different references for numerical comparison and then compare a series of numbers (10–99) to the reference numbers cued by different geometrical figures. The cue repeated or switched across trials. Behavioral results revealed that the switch cost was greater in the large‐size condition than in the small‐size condition. Event‐related potential results showed that in the N2 component, an interaction was observed between set size and transition, with a significant transition effect (switch minus repeat) in the large‐size condition and a non‐significant transition effect in the small‐size condition. The same interaction was observed in the P3 component, with a larger amplitude difference (switch minus repeat) in the large‐size condition than in the small‐size condition. These results suggested that when set size is increased, the effort to inhibit the irrelevant items increases, resulting in large cost of object switching in working memory. In the first ERP study of the neural mechanisms underlying the effect of set size on the cost of object switching in working memory, we showed that the effect of memory set size on switch cost is mirrored in brain potentials in the N2 and P3 components, with a larger amplitude difference (switch minus repeat) in large‐size than small‐size condition, reflecting increased selective inhibition of irrelevant items. [ABSTRACT FROM AUTHOR]