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Study of Different Local Treatments of Post COVID-19 Smell Dysfunction.
- Source :
- Iranian Journal of Otorhinolaryngology; Nov/Dec2022, Vol. 34 Issue 6, p281-288, 8p
- Publication Year :
- 2022
-
Abstract
- Introduction: This study was designed to differentiate between the impact of the topical nasal spray of corticosteroids, antihistamines, a combination of them, and normal 0.2% saline in treating patients with postcoronavirus disease 2019 (COVID-19) smell dysfunction. Materials and Methods: Patients with hyposmia or anosmia (n = 240), who recently recovered from COVID-19, were enrolled in this trial and were randomly assigned to four parallel groups. Group I (G1) received a combination of topical corticosteroid and antihistamine nasal spray (n = 60). Group II (G2) received topical corticosteroid nasal spray (n = 60). Group III (G3) received antihistamine nasal spray (n = 60). Group IV (G4) received 0.2% normal nasal saline nasal spray (n = 60). The treatments were used in all groups for 3 weeks. The sense of smell was assessed using the butanol threshold and discrimination tests. The smell tests were evaluated weekly for 3 weeks. Results: The mean age of the patients was 51.9 ± 7.1 years; moreover, 83.8% and 16.2% were male and female, respectively. The results of the smell tests in the first week significantly improved with those in the third week (P< 0.001). The greatest degree of improvement was found in the first group, followed by the second, third, and fourth groups. Conclusions: The results suggest the ability of combination therapy of corticosteroid and antihistamine nasal spray to manage post-COVID-19 hyposmia or anosmia; however, this combination therapy was not superior to corticosteroid nasal spray. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 22517251
- Volume :
- 34
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Iranian Journal of Otorhinolaryngology
- Publication Type :
- Academic Journal
- Accession number :
- 160661883
- Full Text :
- https://doi.org/10.22038/IJORL.2022.58339.3012