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A Novel Method to Construct 2-Aminobenzofurans via [4 + 1] Cycloaddition Reaction of In Situ Generated Ortho -Quinone Methides with Isocyanides.
- Source :
- Molecules; Dec2022, Vol. 27 Issue 23, p8538, 14p
- Publication Year :
- 2022
-
Abstract
- A new approach for the synthesis of 2-aminobenzofurans has been described via Sc(OTf)<subscript>3</subscript> mediated formal cycloaddition of isocyanides with the in situ generated ortho-quinone methides (o-QMs) from o-hydroxybenzhydryl alcohol. Notably, as a class of readily available and highly active intermediates, o-QMs were first used in the construction of benzofurans. This [4 + 1] cycloaddition reaction provides a straightforward and efficient methodology for the construction of 2-aminobenzofurans scaffold in good yield (up to 93% yield) under mild conditions. [ABSTRACT FROM AUTHOR]
- Subjects :
- ISOCYANIDES
RING formation (Chemistry)
QUINONE
QUINONE derivatives
BENZOFURANS
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 27
- Issue :
- 23
- Database :
- Complementary Index
- Journal :
- Molecules
- Publication Type :
- Academic Journal
- Accession number :
- 160740057
- Full Text :
- https://doi.org/10.3390/molecules27238538