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Polyoxygenated Terpenoids and Polyketides from the Roots of Flueggea virosa and Their Inhibitory Effect against SARS-CoV-2-Induced Inflammation.
- Source :
- Molecules; Dec2022, Vol. 27 Issue 23, p8548, 11p
- Publication Year :
- 2022
-
Abstract
- Six new polyoxygenated terpenoids, podovirosanes A–F (1–6), and two known polyketides (7 and 8) were isolated from the roots of F. virosa. Their structures, along with absolute configurations, were deduced using spectroscopic analysis as well as computational calculations, including TDDFT calculation of ECD spectra and GIAO NMR calculations combined with DP4+ probability analysis. Compounds 2, 3, 5, and 8 were found to reduce the phosphorylation levels of NF-κB p65 in SARS-CoV-2 pseudovirus-stimulated PMA-differentiated THP-1 cells. [ABSTRACT FROM AUTHOR]
- Subjects :
- TERPENES
POLYKETIDES
INFLAMMATION
SARS-CoV-2
PHOSPHORYLATION
PROBABILITY theory
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 27
- Issue :
- 23
- Database :
- Complementary Index
- Journal :
- Molecules
- Publication Type :
- Academic Journal
- Accession number :
- 160740067
- Full Text :
- https://doi.org/10.3390/molecules27238548