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Age-related changes in cell localization and proliferation in lymph nodes and spleen after antigenic stimulation.
- Source :
- Immunology; Aug80, Vol. 40 Issue 4, p687-694, 8p
- Publication Year :
- 1980
-
Abstract
- Antigen-dependent localization of <superscript>51</superscript>Cr- labelled lymphocytes, and the subsequent uptake of IUdR into lymphoid organs has been studied as a function of age. Measures of cell localization indicated that while old age can alter the patterns of entry of lymphocytes into lymph nodes and spleen. these changes are variable and probably not sufficient alone to explain decreased primary antibody responses in old animals. Proliferation of cells, however, was cone sistently affected in both organs and this phenomenon is discussed in terms of abnormal T-cell function. [ABSTRACT FROM AUTHOR]
- Subjects :
- LYMPHOCYTES
ANTIGENS
IMMUNITY
LYMPH nodes
SPLEEN
IMMUNOGLOBULINS
Subjects
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 40
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 16075264