The cell-mediated immune response of the pig to orally administered antigen.

The immune response of pigs to oral immunization with dinitrophenylated bovine gamma globulin (DNP-BGG) was assessed using the indirect macrophage migration assay. Two days' exposure to the antigen resulted in the inhibition of macrophage migration by supernatants of cultures from the intestine but not the mesenteric lymph node or spleen. Stimulation for 7 days resulted in macrophage inhibition by supernatants of lymphocyte cultures prepared from the intestine, mesenteric lymph node and spleen. Supernatants of splenic lymphocytes from animals stimulated for 2 or 3 days produced enhancement of macrophage migration. [ABSTRACT FROM AUTHOR]