Abnormal Dynamic Functional Network Connectivity in Adults with Autism Spectrum Disorder.

Purpose: This study sought to explore changes of brain dynamic functional network connectivity (dFNC) in adults with autism spectrum disorder (ASD) and investigate their relationship with clinical manifestations. Methods: Resting-state functional magnetic resonance imaging (rs-fMRI) data were acquired from 78 adult ASD patients from autism brain imaging data exchange datasets, and 65 age-matched healthy controls subjects from the local community. Independent component analysis was conducted to evaluate dFNC patterns on the basis of 13 independent components (ICs) within 11 resting-state networks (RSN), namely, auditory network (AUDN), basal ganglia network (BGN), language network (LN), sensorimotor network (SMN), precuneus network (PUCN), salience network (SN), visuospatial network (VSN), dorsal default mode network (dDMN), high visual network (hVIS), primary visual network (pVIS), ventral default mode network (vDMN). Fraction time, mean dwell time, number of transitions, and RSN connectivity were calculated for group comparisons. Correlation analyses were performed between abnormal metrics and autism diagnostic observation schedule (ADOS) scores. Results: Compared with controls, ASD patients had higher fraction time and mean dwell time in state 2 (P = 0.017, P = 0.014). Reduced dFNC was found in the SMN with PUCN, SMN with hVIS, and increased dFNC was observed in the dDMN with SN in state 2 in the ASD group. Fraction time and mean dwell time was positively correlated with stereotyped behavior scores of ADOS. Conclusion: The findings demonstrated the importance of evaluating transient alterations in specific neural networks of adult ASD patients. The abnormal metrics and connectivity may be related to symptoms such as stereotyped behavior. [ABSTRACT FROM AUTHOR]