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Ni-catalyzed benzylic β-C(sp3)–H bond activation of formamides.
- Source :
- Nature Communications; 12/22/2022, Vol. 13 Issue 1, p1-9, 9p
- Publication Year :
- 2022
-
Abstract
- The development of transition metal-catalyzed β-C–H bond activation via highly-strained 4-membered metallacycles has been a formidable task. So far, only scarce examples have been reported to undergo β-C–H bond activation via 4-membered metallacycles, and all of them rely on precious metals. In contrast, earth-abundant and inexpensive 3d transition metal-catalyzed β-C–H bond activation via 4-membered metallacycles still remains an elusive challenge. Herein, we report a phosphine oxide-ligated Ni−Al bimetallic catalyst to activate secondary benzylic C(sp<superscript>3</superscript>)–H bonds of formamides via 4-membered nickelacycles, providing a series of α,β-unsaturated γ-lactams in up to 97% yield. The development of 3d-metal-catalyzed β-C–H bond activation via 4-membered metallacycles remains an elusive challenge. Here, the authors report a Ni-Al bimetal-catalyzed β-C(sp3)–H bond activation of formamides via 4-membered nickelacycles. [ABSTRACT FROM AUTHOR]
- Subjects :
- BIMETALLIC catalysts
PRECIOUS metals
BONDS (Finance)
METALLACYCLES
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 13
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- 160936986
- Full Text :
- https://doi.org/10.1038/s41467-022-35541-6