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Gastroprotective Effect of Anisomeles indica on Aspirin-Induced Gastric Ulcer in Mice.
- Source :
- Antioxidants; Dec2022, Vol. 11 Issue 12, p2327, 13p
- Publication Year :
- 2022
-
Abstract
- Gastric ulcers are commonly seen in the upper gastrointestinal tract and may be related to the Helicobacter pylori infection and the use of aspirin, a nonsteroidal anti-inflammatory drug (NSAID). Typically, proton-pump inhibitors (PPIs) are used to treat gastric ulcers; however, adverse effects have emerged following long-term treatment. Natural medicines are used as alternative therapeutic agents in the treatment of gastric ulcers, with few side effects. Despite various reports on the anti-H. pylori and anti-gastric cancer activities of Anisomeles indica, its gastroprotective effect on ulcers remains undetermined. This study investigated the protective effect of A. indica on aspirin-induced gastric ulcers in murine models. Our results show that three fractions of ethanol-extracted A. indica inhibited aspirin-induced gastric injury. Among these, A. indica Fraction 1 was observed to enrich ovatodiolide, which effectively diminished gastric acidity and alleviated aspirin-induced inflammation in the stomach. Our results provide evidence that A. indica could be developed as an effective therapeutic agent for gastroprotective purposes. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20763921
- Volume :
- 11
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Antioxidants
- Publication Type :
- Academic Journal
- Accession number :
- 160942188
- Full Text :
- https://doi.org/10.3390/antiox11122327