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Expression on cells of early human pregnancy decidua, of the p75, IL-2 and p145, IL-4 receptor proteins.
- Source :
- Immunology; May91, Vol. 73 Issue 1, p64-70, 7p
- Publication Year :
- 1991
-
Abstract
- Immunohistological studies of human first trimester pregnancy decidua demonstrated the presence of the p75 interleukin-2 receptor (IL-2R) and the pI45 interleukin-4 receptor protein (IL-4R) on cells in the decidual stroma; there was no expression of CD25, the p55 IL-2R. The IL-4R was also expressed on the basal face of the glandular epithelial cells. Flow cytometric analysis of antibody-labelled decidual cell dispersions confirmed these results. Double antibody labelling demonstrated that p75 was expressed exclusively on the CD56-positive decidual large granular lymphocytes (LGL), whereas the IL4-R was expressed on some decidual LGL, and most decidual macrophages and T cells. In vitro incubation of decidual cells with IL-2 failed to induce expression of p55 or to increase the expression of either p75 or the pI45 IL-4R. Purified decidual LGL proliferated in vitro in response to IL-2, and IL-4 inhibited this IL-2-induced proliferation. [ABSTRACT FROM AUTHOR]
- Subjects :
- INTERLEUKINS
T cells
LYMPHOCYTES
EPITHELIAL cells
LEUCOCYTES
MONONUCLEOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 73
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 16100399