Approaching Challenges Posed by SARS-CoV-2 Genetic Variants.

For vaccine development, quantum vaccinology and vaccinomics approaches could be applied for the identification and combination of protective epitopes alone or in combination with post-translational modifications, such as glycans in chimeric antigens, to enhance vaccine efficacy against multiple virus genetic variants [[40], [42], [44], [46]]. 10.3390/ijms21186702 45 Galili U. Amplifying immunogenicity of prospective Covid-19 vaccines by glycoengineering the coronavirus glycan-shield to present -gal epitopes. Vaccines have been the most effective intervention for the control of COVID-19, which, together with improved virus infection diagnostics, epidemiological surveillance, and treatment, have reduced disease prevalence and symptomatology (Figure 1). In this new collection of the most viewed and cited papers, one of the Editor's chosen articles, published in I Pathogens i in 2021, addressed the impact and the concerns relating to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants [[1]]. [Extracted from the article]