Comparing the diagnostic value of 18F-FDG PET/CT scan and bone marrow biopsy in newly diagnosed pediatric neuroblastoma and ganglioneuroblastoma .

Objective: This study aims to compare the diagnostic value of ¹⁸Ffluorodeoxyglucose (¹⁸F-DG) positron emission tomography (PET)/ computed tomography (CT) (¹⁸F-FDG PET/CT) scan and bone marrow biopsy (BMB) for evaluating bone marrow infiltration (BMI) in newly diagnosed pediatric neuroblastoma (NB) and ganglioneuroblastoma (GNB). Methods: We retrospectively reviewed 51 patients with newly diagnosed NB and GNB between June 1, 2019 and May 31, 2022. Each patient had undergone ¹⁸F-FDG PET/CT and BMB within 1 week and received no treatment. Clinical data were collected and statistically analyzed, including age, sex, pathologic type, and laboratory parameters. ¹⁸F-FDG PET/CT and BMB revealed the result of bone lesions. Results: A concordance analysis showed that, in this study population, ¹⁸F-FDG PET/CT and BMB were in moderate agreement (Cohen’s Kappa = 0.444; p = 0.001), with an absolute agreement consistency of 72.5% (37 of 51). The analysis of the receiver operating characteristic (ROC) curve determined that the areas under the ROC curve (AUCs) of SUV_BM and SUV/HE-SUV_max were 0.971 (95% CI: 0.911–1.000; p < 0.001) and 0.917 (95% CI: 0.715–1.000; p < 0.001) to predict bone–bone marrow involvement (BMI), respectively. Conclusion: ¹⁸F-FDG PET/CT detects BMI with good diagnostic accuracy and can reduce unnecessary invasive inspections in newly diagnosed pediatric NB and GNB, especially patterns C and D. The analysis of the semi-quantitative uptake of ¹⁸F-FDG, including SUV_BM and SUV_BM/HE-SUV_max, enables an effective differentiation between patterns A and B. [ABSTRACT FROM AUTHOR]