First-trimester screening for aneuploidy in HIV-positive pregnant women under HAART .

Introduction. Human immunodeficiency virus (HIV), that ultimately determines the development of AIDS, evolved in time in a pandemic disease. Objectives. Our study evaluated first-trimester markers for aneuploidy in HIV-positive pregnant women under HAART (highly active antiretroviral therapy). Materials and method. This was a prospective study that took place between January 2018 and December 2019 in the “Cuza Vodă” Clinical Hospital of Obstetrics and Gynecology, Iaşi, Romania. We analyzed first-trimester PAPP-A (pregnancy-associated plasma protein A) and βHCG (β human chorionic gonadotropin) levels in 25 HIV-positive pregnant women under HAART and compared them with the values of these markers in 31 seronegative pregnant women. Results. Both βHCG and PAPP-A were lower in HIV-positive women under HAART. Discussion. These alterations of first-trimester markers for aneuploidy might lead to an overestimation of the risk for Down syndrome. Conclusions. Obstetricians need to know the alterations of first-trimester markers for aneuploidy, so that they can correctly advise these women accordingly. [ABSTRACT FROM AUTHOR]