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B-Cell Activating Properties of Polymyxin B.
- Source :
- Scandinavian Journal of Immunology; Jan1978, Vol. 7 Issue 1, p67-72, 6p
- Publication Year :
- 1978
-
Abstract
- Polymyxins are known to be inhibitors of certain polyclonal B cell activators such as lipopolysaccharide and dextransulphate. However, increased specific responses to hapten-coupled mitogens have been reported after the addition of polymyxins to superoptimal conjugate doses. In this paper we have studied the effect of polymyxin B on superoptimal polyclonal doses of lipopolysaccharide. Results similar to those reported for hapten-lipopolysaccharide conjugates were obtained. Polymyxin B was also found to exert adjuvant properties for a primary immune response to sheep erythrocytes and to be a thymus-independent antigen. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03009475
- Volume :
- 7
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Scandinavian Journal of Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 16114533
- Full Text :
- https://doi.org/10.1111/j.1365-3083.1978.tb00427.x