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Mechanisms Involved in Age-dependent Decline of Immune Responsiveness and Apparent Resistance against Tolerance Induction in C57BL/6 Mice.
- Source :
- Scandinavian Journal of Immunology; Sep1982, Vol. 16 Issue 3, p217-231, 15p
- Publication Year :
- 1982
-
Abstract
- The plaque-forming antibody response of C57BL/6 mice to rabbit gamma globulin (RGG) decreases as a function of age. RGG in tolerogenic form induces tolerance of young mice but sensitizes older animals. If antigen is administered together with lipopolysaccharide, the age-dependent decline in immune responsiveness is not observed, nor are older animals sensitized by tolerogen. The age-dependent decline in immune responsiveness is due to a loss of T helper capacity; sensitization by tolerogen is attributable to a subpopulation of B cells which becomes sensitized by the tolerogen. Older animals, treated with tolerogen, show a degree of central tolerance of T cells and a relatively slight, age-dependent diminution in colchicine- or cyclophosphamide-sensitive precursors of suppressor cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03009475
- Volume :
- 16
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Scandinavian Journal of Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 16129289
- Full Text :
- https://doi.org/10.1111/j.1365-3083.1982.tb00717.x