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Genetic and Phenotypic Characteristics of Carbapenem-Resistant Klebsiella pneumoniae Isolates from a Tertiary Hospital in Beijing.
- Source :
- Infection & Drug Resistance; Dec2022, Vol. 15, p7503-7508, 6p
- Publication Year :
- 2022
-
Abstract
- aimed to study the phenotypic and genotypic characteristics of carbapenem-resistant K. pneumoniae (CRKP) isolates from a hospital in Beijing. Methods: Twenty-four CRKP clinical isolates were collected within a half-year to investigate antimicrobial resistance and genomic characteristics. Illumina and Nanopore sequencing were performed to assemble and annotate genomes. Results: All strains were multi-drug resistant. Twenty-two strains carried the bla<subscript>KPC-2</subscript> gene and two harbored bla<subscript>NDM-5</subscript>. Multilocus sequence type(MLST) analysis identified five sequence types; most isolates belonged to ST11. Three strains were isolated from the same patient; each carried a different plasmid replicon, either IncFII <subscript>(pHN7A8)</subscript>, IncX, or IncFIB <subscript>(K)</subscript>. Conclusion: This study furthers the understanding of CRKP antimicrobial resistance genotypes, and may facilitate the control of nosocomial infections caused by antimicrobial-resistant pathogens. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 11786973
- Volume :
- 15
- Database :
- Complementary Index
- Journal :
- Infection & Drug Resistance
- Publication Type :
- Academic Journal
- Accession number :
- 161298763
- Full Text :
- https://doi.org/10.2147/IDR.S395920