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Association of Catalase Gene Polymorphisms with Idiopathic Nephrotic Syndrome in a Chinese Pediatric Population.
- Source :
- Laboratory Medicine; Jan2023, Vol. 54 Issue 1, p35-40, 6p
- Publication Year :
- 2023
-
Abstract
- Objective Our aim was to investigate the association between gene polymorphisms in catalase (CAT), a well-known oxidative stress regulator, and susceptibility to idiopathic nephrotic syndrome (INS) or responses to steroid therapy in a Chinese pediatric population. Methods We analyzed 3 CAT single-nucleotide polymorphisms (SNVs; rs7943316, rs769217, and rs12270780) using multi-polymerase chain reaction combined with next-generation sequencing in 183 INS patients and 100 healthy controls. Results For the allele and genotype frequencies of the CAT SNVs, no significant differences were observed between INS patients and controls. Patients with C allele of CAT rs769217 had a higher risk of developing steroid-dependent nephrotic syndrome than the steroid-sensitive nephrotic syndrome patients (P = 0.018; odds ratio = 1.76). Conclusion Our data suggests that genetic variations in CAT were unlikely to confer susceptibility to INS in Chinese children, whereas the C allele of the CAT rs769217 polymorphism showed a strong association with steroid-dependent responses in Chinese INS children. [ABSTRACT FROM AUTHOR]
- Subjects :
- GENETICS of disease susceptibility
STEROID drugs
SEQUENCE analysis
SINGLE nucleotide polymorphisms
NEPHROTIC syndrome
MANN Whitney U Test
CATALASE
RISK assessment
T-test (Statistics)
DISEASE susceptibility
CHI-squared test
DESCRIPTIVE statistics
POLYMERASE chain reaction
DATA analysis software
NEPHROTIC syndrome in children
DISEASE risk factors
CHILDREN
Subjects
Details
- Language :
- English
- ISSN :
- 00075027
- Volume :
- 54
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Laboratory Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 161404448
- Full Text :
- https://doi.org/10.1093/labmed/lmac062