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Kinetics of the serological response up to one year after tularemia.
- Source :
- Frontiers in Cellular & Infection Microbiology; 6/1/2023, Vol. 12, p1-7, 7p
- Publication Year :
- 2023
-
Abstract
- Serological analysis is the predominant method used to diagnose tularemia, a zoonotic disease caused by the highly virulent bacterium F. tularensis. We determined F. tularensis-specific IgM and IgG antibody titers by an LPS-based ELISA assay on five occasions one to twelve months after onset of ulceroglandular tularemia in 19 individuals. Peak IgM antibody titers were observed at the one-month time point and peak IgG antibody titers at the two-month time point. Both IgG and IgM antibody levels declined linearly thereafter with rather similar kinetics. Compared to the average one-month antibody titers, average IgG titers were not significantly lower before the 12-month time point and IgM titers before the 4-month time point. All, but one average titer, were significantly increased compared to the cut-off of the assay. Average IgG and IgM titers were significantly lower for the group = 69 years old compared to the group < 69 years. Collectively, the data demonstrate a persistence of F. tularensis-specific IgM and IgG antibody titers for at least 12 months after ulceroglandular tularemia. Thus, low, but significantly elevated F. tularensis-specific antibody titers are of limited diagnostic value since they are not indicative of ongoing tularemia. [ABSTRACT FROM AUTHOR]
- Subjects :
- TULAREMIA
ANTIBODY titer
ZOONOSES
IMMUNOGLOBULIN G
TITERS
Subjects
Details
- Language :
- English
- ISSN :
- 22352988
- Volume :
- 12
- Database :
- Complementary Index
- Journal :
- Frontiers in Cellular & Infection Microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 161427349
- Full Text :
- https://doi.org/10.3389/fcimb.2022.1072703