Back to Search Start Over

Coagulation Disorders in Sepsis and COVID-19—Two Sides of the Same Coin? A Review of Inflammation–Coagulation Crosstalk in Bacterial Sepsis and COVID-19.

Authors :
Tuculeanu, Georgeana
Barbu, Ecaterina Constanta
Lazar, Mihai
Chitu-Tisu, Cristina Emilia
Moisa, Emanuel
Negoita, Silvius Ioan
Ion, Daniela Adriana
Source :
Journal of Clinical Medicine; Jan2023, Vol. 12 Issue 2, p601, 27p
Publication Year :
2023

Abstract

Sepsis is a major cause of morbidity and mortality worldwide. Sepsis-associated coagulation disorders are involved in the pathogenesis of multiorgan failure and lead to a subsequently worsening prognosis. Alongside the global impact of the COVID-19 pandemic, a great number of research papers have focused on SARS-CoV-2 pathogenesis and treatment. Significant progress has been made in this regard and coagulation disturbances were once again found to underlie some of the most serious adverse outcomes of SARS-CoV-2 infection, such as acute lung injury and multiorgan dysfunction. In the attempt of untangling the mechanisms behind COVID-19-associated coagulopathy (CAC), a series of similarities with sepsis-induced coagulopathy (SIC) became apparent. Whether they are, in fact, the same disease has not been established yet. The clinical picture of CAC shows the unique feature of an initial phase of intravascular coagulation confined to the respiratory system. Only later on, patients can develop a clinically significant form of systemic coagulopathy, possibly with a consumptive pattern, but, unlike SIC, it is not a key feature. Deepening our understanding of CAC pathogenesis has to remain a major goal for the research community, in order to design and validate accurate definitions and classification criteria. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20770383
Volume :
12
Issue :
2
Database :
Complementary Index
Journal :
Journal of Clinical Medicine
Publication Type :
Academic Journal
Accession number :
161478626
Full Text :
https://doi.org/10.3390/jcm12020601