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Recovery of systemic hyperinflammation in patients with severe SARS-CoV-2 infection.

Authors :
Langnau, Carolin
Janing, Henrik
Kocaman, Hüseyin
Gekeler, Sarah
Günter, Manina
Petersen-Uribe, Álvaro
Jaeger, Philippa
Koch, Barbara
Kreisselmeier, Klaus-Peter
Castor, Tatsiana
Rath, Dominik
Gawaz, Meinrad Paul
Autenrieth, Stella E.
Mueller, Karin Anne Lydia
Source :
Biomarkers; Feb2023, Vol. 28 Issue 1, p97-110, 14p
Publication Year :
2023

Abstract

Patients with cardiovascular disease (CVD) and acute SARS-CoV-2 infection might show an altered immune response during COVID-19. Twenty-three patients with CVD and SARS-CoV-2 infection were prospectively enrolled and received a cardiological assessment at study entry and during follow-up visit. Inclusion criteria of our study were age older than 18 years, presence of CVD, and acute SARS-CoV-2 infection. The median age of the patient cohort was 69 (IQR 55–79) years. 12 (52.2%) patients were men. Peripheral monocytes and chemokine/cytokine profiles were analysed. Numbers of classical and non-classical monocytes were significantly decreased during acute SARS-CoV-2 infection compared to 3-month recovery. While classical monocytes reached the expected level in peripheral blood after 3 months, the number of non-classical monocytes remained significantly reduced. All three monocyte subsets exhibited changes of established adhesion and activation markers. Interestingly, they also expressed higher levels of pro-inflammatory cytokines like macrophage migration inhibitory factor (MIF) at the time of recovery, although MIF was only slightly increased during the acute phase. Changes of monocyte phenotypes and increased MIF expression after 3-month recovery from acute SARS-CoV-2 infection may indicate persistent, possibly long-lasting, pro-inflammatory monocyte function in CVD patients. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1354750X
Volume :
28
Issue :
1
Database :
Complementary Index
Journal :
Biomarkers
Publication Type :
Academic Journal
Accession number :
161588108
Full Text :
https://doi.org/10.1080/1354750X.2022.2148745